GW-0742 Powder

Introduction to GW-0742 Powder

GW-0742 powder is a synthetic research chemical widely studied in laboratory settings for its interaction with metabolic pathways. Classified as a selective PPAR-δ (Peroxisome Proliferator-Activated Receptor Delta) agonist, this compound has attracted attention in scientific research related to energy metabolism, inflammation, and lipid regulation.

It is important to emphasize that GW-0742 is strictly intended for research purposes only and is not approved for human consumption.


Chemical Profile of GW-0742

  • Chemical Name: 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
  • CAS Number: 317318-84-6
  • Molecular Formula: C₂₁H₁₇F₄NO₃S₂
  • Molecular Weight: 471.49 g/mol
  • Appearance: Typically a white to light-yellow solid
  • Solubility: Soluble in DMSO and ethanol under controlled conditions

GW-0742 powder is often preferred in research environments due to its stability and flexibility for solution preparation.


Mechanism of Action

GW-0742 functions as a high-affinity PPAR-δ agonist, meaning it binds to and activates this nuclear receptor, influencing gene expression involved in metabolic processes.

Activation of PPAR-δ is associated with:

  • Regulation of fatty acid oxidation
  • Modulation of energy expenditure
  • Influence on lipid metabolism pathways

Research suggests that this mechanism allows scientists to explore how metabolic systems adapt to different stimuli at the cellular level.


Research Applications

GW-0742 powder is utilized in various experimental studies, including:

1. Metabolic Research

Scientists investigate its role in lipid metabolism and energy balance, particularly how cells utilize fatty acids for energy.

2. Inflammation Studies

GW-0742 has been observed to influence inflammatory markers such as TNF-α and IL-1β in experimental models.

3. Cardiovascular and Cellular Studies

Research explores its potential effects on:

  • Vascular function
  • Oxidative stress
  • Cellular signaling pathways

4. Neurological and Radiation Studies

Some studies indicate it may help modulate responses to radiation-induced damage in controlled lab conditions.


Storage and Handling

Proper storage is critical to maintaining the integrity of GW-0742 powder:

  • Store at −20°C for long-term stability
  • Avoid repeated freeze-thaw cycles
  • Prepare stock solutions in appropriate solvents (e.g., DMSO)
  • Use aliquots to preserve compound activity

These practices help ensure reproducibility in experimental research.


Safety and Disclaimer

GW-0742 is:

  • Not approved for human or veterinary use
  • Intended only for laboratory research
  • Lacking comprehensive clinical safety data

Handling should follow strict laboratory safety protocols, including the use of protective equipment and controlled environments.

GW-0742 Powder
GW-0742 Powder

Conclusion

GW-0742 powder represents a valuable tool in metabolic and biochemical research, particularly in the study of PPAR-δ signaling pathways. Its high selectivity and potency make it useful for investigating energy regulation, inflammation, and cellular responses in experimental settings.

However, due to its research-only status, it should be used exclusively by qualified professionals in controlled laboratory environments.

 

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